Cross-talk between FGF and other cytokine signalling pathways during endochondral bone development

Min Jin; Xiaolan Du; Lin Chen

doi:10.1042/CBI20110352

Cross-talk between FGF and other cytokine signalling pathways during endochondral bone development

Cell Biol Int. 2012 Aug 1;36(8):691-6. doi: 10.1042/CBI20110352.

Authors

Min Jin¹, Xiaolan Du, Lin Chen

Affiliation

¹ State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Peoples Republic of China.

PMID: 22803513
DOI: 10.1042/CBI20110352

Abstract

FGF (fibroblast growth factor)/FGFR (FGF receptor) signalling plays an essential role in both endochondral and intramembranous bone development. FGF signalling pathways are important for the earliest stages of limb development and throughout skeletal development. The activity and the outcome of this signalling pathway during bone development are also influenced by many other intracellular and extracellular signals. In this review, we focus on the interplay between FGF signalling and other pathways, which is tightly regulated both spatially and temporally during endochondral skeletal development.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bone Development / physiology*
Bone Morphogenetic Proteins / metabolism
Cytokines / metabolism*
Fibroblast Growth Factors / metabolism*
Hedgehog Proteins / metabolism
Humans
Phosphatidylinositol 3-Kinases / metabolism
Proto-Oncogene Proteins c-akt / metabolism
Receptors, Fibroblast Growth Factor / metabolism
Signal Transduction*
Wnt Proteins / metabolism

Substances

Bone Morphogenetic Proteins
Cytokines
Hedgehog Proteins
Receptors, Fibroblast Growth Factor
Wnt Proteins
Fibroblast Growth Factors
Phosphatidylinositol 3-Kinases
Proto-Oncogene Proteins c-akt