Candida albicans is one of the most important conditional pathogens. Calcium homeostasis systems and calcium signaling in this pathogen are closely associated with numerous physiological processes, such as pathogenesis and stress responses. Study on calcium homeostasis systems and calcium signaling pathways will illuminate its calcium-related mechanisms of pathogenesis and drug resistance, and establish new therapeutic strategies for fungal infections. This review introduced the advances in the study in these fields.