The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women

Endocrine. 2013 Feb;43(1):127-35. doi: 10.1007/s12020-012-9726-8. Epub 2012 Jul 14.

Abstract

To investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and non-genetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women. Five SNPs in genes GPR177, CTNNB1, MEF2C, SOX6, and TNFRSF11B were associated with L1-4 or total hip BMDs. rs11898505 in SPTBN1 gene was associated with osteoporotic fractures. Subjects carrying the largest number of risk alleles (highest 10 %) not only had lower BMD values as compared to those carrying the least number of risk alleles (lowest 10 %), they also had a higher risk of fracture [P = 0.002, OR = 2.252, 95 %CI (1.136, 4.463)]. Results from multivariate stepwise regression analysis revealed that age [P < 0.001, OR = 1.038, 95 % CI (1.018, 1.058)], number of falls in a year [P < 0.001, OR = 2.347, 95 % CI (1.459, 3.774)], the G risk allele in rs11898505 [P = 0.023, OR = 1.559, 95 % CI (1.062, 2.290)], and the L1-4 BMD [P = 0.017, OR = 0.286, 95 % CI (0.102, 0.798)] were associated with the occurrence of osteoporotic fractures. Genetic (rs11898505) and non-genetic factors (age, number of falls in a year and L1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Accidental Falls
  • Adult
  • Aged
  • Aging*
  • Asian People
  • Bone Density
  • China
  • Cohort Studies
  • Cross-Sectional Studies
  • Female
  • Genetic Association Studies
  • Hip Joint / diagnostic imaging
  • Hip Joint / metabolism
  • Humans
  • Lumbar Vertebrae / diagnostic imaging
  • Lumbar Vertebrae / metabolism*
  • MADS Domain Proteins / genetics*
  • MADS Domain Proteins / metabolism
  • MEF2 Transcription Factors
  • Middle Aged
  • Myogenic Regulatory Factors / genetics*
  • Myogenic Regulatory Factors / metabolism
  • Osteoporosis, Postmenopausal / ethnology
  • Osteoporosis, Postmenopausal / genetics
  • Osteoporosis, Postmenopausal / metabolism
  • Osteoporosis, Postmenopausal / physiopathology
  • Osteoporotic Fractures / ethnology
  • Osteoporotic Fractures / etiology*
  • Osteoporotic Fractures / genetics
  • Osteoporotic Fractures / metabolism
  • Osteoprotegerin / genetics*
  • Osteoprotegerin / metabolism
  • Polymorphism, Single Nucleotide*
  • Radiography
  • Spectrin / genetics*
  • Spectrin / metabolism
  • Young Adult

Substances

  • MADS Domain Proteins
  • MEF2 Transcription Factors
  • MEF2C protein, human
  • Myogenic Regulatory Factors
  • Osteoprotegerin
  • SPTBN1 protein, human
  • TNFRSF11B protein, human
  • Spectrin