Characterization of the mechanical and biological properties of a new alumina scaffold

J Appl Biomater Funct Mater. 2013 Jun 24;11(1):e18-25. doi: 10.5301/JABFM.2012.9264.

Abstract

Purpose: In this work, an alumina scaffold was produced through a new method to be used in a near future as a bone substitute.

Methods: In vitro and in vivo studies were performed in order to characterize the mechanical and biological properties of the scaffold.

Results: The results obtained showed that this scaffold has high mechanical resistance and a porous surface that allows human osteoblast cells to adhere and proliferate. The in vivo studies revealed no systemic reaction.

Conclusions: The alumina scaffold produced herein has the mechanical and biological properties that are compatible with its application in bone therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aluminum Oxide / chemistry*
  • Aluminum Oxide / pharmacology*
  • Animals
  • Bone Regeneration / drug effects
  • Bone Substitutes / chemical synthesis
  • Bone Substitutes / chemistry
  • Bone Substitutes / pharmacology
  • Cells, Cultured
  • Humans
  • Materials Testing
  • Mechanical Phenomena*
  • Osteoblasts / drug effects
  • Osteoblasts / physiology
  • Rats
  • Rats, Wistar
  • Tissue Engineering / methods
  • Tissue Scaffolds* / chemistry

Substances

  • Bone Substitutes
  • Aluminum Oxide