Preclinical testing of Peruvian anti-bothropic anti-venom against Bothrops andianus snake venom

Toxicon. 2012 Nov;60(6):1018-21. doi: 10.1016/j.toxicon.2012.06.018. Epub 2012 Jul 14.

Abstract

Bothrops andianus is a venomous snake found in the area of Machu Picchu (Peru). Its venom is not included in the antigenic pool used for production of the Peruvian anti-bothropic anti-venom. B. andianus venom can elicit many biological effects such as hemorrhage, hemolysis, proteolytic activity and lethality. The Peruvian anti-bothropic anti-venom displays consistent cross-reactivity with B. andianus venom, by ELISA and Western Blotting and is also effective in neutralizing the venom's toxic activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antivenins / pharmacology*
  • Blotting, Western
  • Bothrops
  • Cross Reactions
  • Drug Evaluation, Preclinical
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hemolysis / drug effects
  • Hemorrhage / physiopathology
  • Male
  • Mice
  • Peru
  • Proteolysis / drug effects
  • Snake Venoms / chemistry*

Substances

  • Antivenins
  • Snake Venoms