Abstract
Solutions containing diclofenac (M) and a copper salt [CuCl2, Cu(ClO4)2, Cu(NO3)2, CuSO4) were analysed by electrospray ionisation mass spectrometry (ESI-MS). Because of the cation-pi interactions in diclofenac-Cu(II) complexes, the diclofenac molecular ion M+* at m/z 295 was formed. It was found that the solvent composition (methanol versus water/methanol) and counter ion strongly affect the M+* ion formation. Formation pathways of ion M+* are discussed.
MeSH terms
-
Anti-Inflammatory Agents, Non-Steroidal / chemistry*
-
Copper / chemistry*
-
Copper Sulfate / chemistry
-
Diclofenac / chemistry*
-
Ions / chemistry*
-
Methanol / chemistry
-
Nitrates / chemistry
-
Perchlorates / chemistry
-
Solutions
-
Spectrometry, Mass, Electrospray Ionization*
-
Water / chemistry
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Ions
-
Nitrates
-
Perchlorates
-
Solutions
-
Water
-
copper(II) perchlorate
-
Diclofenac
-
Copper
-
copper(II) nitrate
-
Copper Sulfate
-
cupric chloride
-
Methanol