Non-classical congenital adrenal hyperplasia in association with porphyria cutanea tarda: co-incidence or trigger?

Ann Clin Biochem. 2012 Sep;49(Pt 5):500-2. doi: 10.1258/acb.2011.011170. Epub 2012 Jul 10.

Abstract

We present an interesting case of porphria cutanea tarda with hereditary haemochromatosis and non-classical congenital adrenal hyperplasia in a postmenopausal woman. This unusual combination of conditions does not appear to be reported in the literature. The exact mechanism causing porphyria in this patient is not clear. We consider the possibility that in addition to iron accumulation and excess alcohol, altered steroid milieu may have been a possible trigger for the development of bullous lesions in this patient.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Hyperplasia, Congenital / complications*
  • Adrenal Hyperplasia, Congenital / pathology
  • Androgens / blood
  • Female
  • Humans
  • Middle Aged
  • Porphyria Cutanea Tarda / complications*
  • Porphyria Cutanea Tarda / pathology
  • Porphyrins / blood

Substances

  • Androgens
  • Porphyrins