Fully automated sequential solid phase approach towards viral RNA-nucleopeptides

Chem Commun (Camb). 2012 Aug 21;48(65):8093-5. doi: 10.1039/c2cc33477a. Epub 2012 Jul 10.

Abstract

The synthesis of two ribonucleoprotein fragments of unprecedented complexity is reported. These hybrid biomolecules are prepared combining the use of an automated solid phase peptide and oligonucleotide synthesizer on a single solid support.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Molecular Sequence Data
  • Oligonucleotides / chemical synthesis*
  • Oligonucleotides / chemistry
  • Peptides / chemical synthesis*
  • Peptides / chemistry
  • Poliovirus / chemistry*
  • RNA, Viral / chemical synthesis
  • RNA, Viral / chemistry*
  • Ribonucleoproteins / chemical synthesis*
  • Ribonucleoproteins / chemistry
  • Solid-Phase Synthesis Techniques / methods*
  • Viral Proteins / chemical synthesis*
  • Viral Proteins / chemistry

Substances

  • Oligonucleotides
  • Peptides
  • RNA, Viral
  • Ribonucleoproteins
  • Viral Proteins