[Preparation and in vitro release characteristics of pulsed-release tablets of Apocynum venetum]

Zhongguo Zhong Yao Za Zhi. 2011 Jun;36(11):1427-30.
[Article in Chinese]

Abstract

Objective: Using Apocynum venetum as a model drug to prepare pulsed-release tablets based on diffusion, swelling, osmotic pressure mechanism and to evaluate the release characteristics.

Method: The pulsatile release tablets were prepared by film coating methods using HPMC E5 and Eudragit The effect of formulation on pulsatile release of A. venetum was investigated.

Result: The pulsed-release tablet was prepared by a swelling layer coating which contains HPMC E5 and a controlled-release membrane containning Eudragit. The delayed release time of the tablets was (5.0 +/- 0.5) h.

Conclusion: The pulsatile release characteristics of A. venetum pulsatile release tablets were confirmed in vitro.

Publication types

  • English Abstract

MeSH terms

  • Apocynum / chemistry*
  • Delayed-Action Preparations / chemistry
  • Diffusion
  • Drug Compounding / methods*
  • Drugs, Chinese Herbal / chemistry
  • In Vitro Techniques
  • Lactose / analogs & derivatives
  • Lactose / analysis
  • Methylcellulose / analogs & derivatives
  • Methylcellulose / analysis
  • Osmotic Pressure
  • Plant Leaves / chemistry
  • Polymethacrylic Acids / analysis
  • Solubility
  • Tablets / chemistry*
  • Time Factors

Substances

  • Delayed-Action Preparations
  • Drugs, Chinese Herbal
  • Polymethacrylic Acids
  • Tablets
  • hydroxypropylmethylcellulose-lactose matrix
  • methylmethacrylate-methacrylic acid copolymer
  • Methylcellulose
  • Lactose