The asymmetric synthesis of CF3- or -CF2-substituted tetrahydroquinolines by employing a chiral phosphoric acid as catalyst

Chem Commun (Camb). 2012 Aug 11;48(62):7738-40. doi: 10.1039/c2cc18064b.

Abstract

CF(3)- or -CF(2)-containing tetrahydroquinolines have been asymmetrically synthesized from the reaction of fluorinated N-arylimines with benzyl N-vinylcarbamate in the presence of a chiral phosphoric acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Hydrocarbons, Fluorinated / chemical synthesis*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Phosphoric Acids / chemistry*
  • Quinolines / chemistry*
  • Stereoisomerism
  • Urethane / analogs & derivatives*
  • Urethane / chemistry

Substances

  • Hydrocarbons, Fluorinated
  • Phosphoric Acids
  • Quinolines
  • Urethane
  • vinyl carbamate
  • 1,2,3,4-tetrahydroquinoline