Abstract
Proper control of intercellular communication through the Wnt signaling pathway is of critical importance for many aspects of biology, including head formation during vertebrate embryogenesis. A recent Cell paper describes the discovery of a novel protein, TIKI, which controls head size through a surprising new mechanism of Wnt antagonism.
MeSH terms
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Animals
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Head / physiology
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Metalloproteases / genetics
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Metalloproteases / metabolism
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Mutation
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Wnt Proteins / antagonists & inhibitors
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Wnt Proteins / genetics
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Wnt Proteins / metabolism*
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Wnt Signaling Pathway
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Xenopus
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Xenopus Proteins / genetics
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Xenopus Proteins / metabolism
Substances
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TRABD2A protein, Xenopus
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Wnt Proteins
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Xenopus Proteins
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Metalloproteases