Isolation, biological activity, synthesis, and medicinal chemistry of the pederin/mycalamide family of natural products

Nat Prod Rep. 2012 Sep;29(9):980-95. doi: 10.1039/c2np20052j. Epub 2012 Jul 9.

Abstract

This review highlights the broad range of science that has arisen from the isolation of pederin, the mycalamides, theopederins, and onnamides, and psymberin. Specific topics include structure determination, biological activity, synthesis, and analog preparation and analysis.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology
  • Biological Products*
  • Chemistry, Pharmaceutical
  • Coleoptera
  • Coumarins
  • Drug Screening Assays, Antitumor
  • Leukemia P388
  • Molecular Structure
  • Porifera
  • Pyrans* / chemistry
  • Pyrans* / metabolism
  • Pyrans* / pharmacology
  • Pyrones
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Biological Products
  • Coumarins
  • Pyrans
  • Pyrones
  • psymberin
  • mycalamide A
  • pederin