Chronic heart failure is a slowly progressive cardiodepressant process. Systematic physical activity can be an effective tool of preventing and curing cardiac insufficiency. Great significance in the connection between regular physical effort and its cardioprotective effect has the vascular endothelium, secreted pro-inflammatory factors, cytokines and markers ofoxidative stress. Miokins--belonging to the group of cytokines, secretes from muscle fibres under the influence of physical effort plays a substantial role in the improvement of metabolism of skeletal muscles, mobilizing energy resource, and in the growth of muscle mass and angiogenesis. Compensating complex mechanisms including functional and structural changes lead to the processs of reconstruction and increment of cardiac muscle mass, acceleration of the heart rhythm and centralization of blood circulation. The beneficial influence of physical effort on the improvement in the exercise tolerance and quality of life results from influence at autonomous system, neurohormone mechanisms and the muscle metabolism.