Abstract
We proposed a method of synthesis to produce [11C]Choline using TRACERlab FXc module that utilized gas phase iodination. The product had radiochemical purity of 99.79 ± 0.14 % and specific activity of 45.7 ± 7.59 GBq/μmol. [11C]Choline did not have at the moment a specific monograph in European Pharmacopeia therefore we used, when possible, as quality controls reference the monograph of [18F]FDG and we proposed suitable methods to verify radiochemical purity and to quantify residual DMAE and choline amounts.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbon Radioisotopes
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Chemistry Techniques, Synthetic / instrumentation*
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Chemistry Techniques, Synthetic / standards
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Choline / chemical synthesis*
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Choline / chemistry
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Drug Stability
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Endotoxins / analysis
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Gases / chemistry
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Halogenation
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Hydrogen-Ion Concentration
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Osmolar Concentration
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Quality Control
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Radiochemistry / instrumentation*
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Radiochemistry / standards
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Solvents / chemistry
Substances
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Carbon Radioisotopes
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Endotoxins
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Gases
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Solvents
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Choline