Catalytic signal amplification of gold nanoparticles combining with conformation-switched hairpin DNA probe for hepatitis C virus quantification

Wen Li; Ping Wu; Hui Zhang; Chenxin Cai

doi:10.1039/c2cc33635a

Catalytic signal amplification of gold nanoparticles combining with conformation-switched hairpin DNA probe for hepatitis C virus quantification

Chem Commun (Camb). 2012 Aug 14;48(63):7877-9. doi: 10.1039/c2cc33635a. Epub 2012 Jul 3.

Authors

Wen Li¹, Ping Wu, Hui Zhang, Chenxin Cai

Affiliation

¹ Jiangsu Key Laboratory of New Power Batteries, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, P. R. China.

PMID: 22751549
DOI: 10.1039/c2cc33635a

Abstract

We report a new strategy for electrochemical detection of hepatitis C virus (HCV) based on the electrocatalytic signal amplification of gold nanoparticles (AuNPs) combining with a conformation-switched hairpin DNA probe for improving selectivity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
DNA Probes / chemistry
DNA Probes / metabolism*
Electrochemical Techniques
Gold / chemistry*
Hepacivirus / genetics*
Metal Nanoparticles / chemistry*
Nucleic Acid Conformation
Oxidation-Reduction
Oxygen / chemistry
RNA, Viral / analysis

Substances

DNA Probes
RNA, Viral
Gold
Oxygen