Acute cerebellar infarction associated with intravenous gammaglobulin treatment in idiopathic thrombocytopenic purpura

J Stroke Cerebrovasc Dis. 2012 Nov;21(8):917.e9-11. doi: 10.1016/j.jstrokecerebrovasdis.2012.05.006. Epub 2012 Jun 29.

Abstract

Intravenous immunoglobulins (IVIGs) are used for a variety of immunologic and hematologic disorders. Hemorheologic alteration or the rapid increase of platelet counts by IVIG administration can cause thrombotic adverse events. We present a 58-year-old woman with a previous diagnosis of idiopathic thrombocytopenic purpura who developed cerebellar infarction immediately after IVIG treatment. We discuss a possible role of IVIG in cerebral ischemia and management strategies.

Publication types

  • Case Reports

MeSH terms

  • Aspirin / therapeutic use
  • Brain Infarction / chemically induced*
  • Brain Infarction / diagnosis
  • Brain Infarction / drug therapy
  • Cerebellum / blood supply*
  • Cerebellum / drug effects*
  • Cerebellum / pathology
  • Cerebral Angiography / methods
  • Female
  • Humans
  • Immunoglobulins, Intravenous / administration & dosage
  • Immunoglobulins, Intravenous / adverse effects*
  • Infusions, Intravenous
  • Magnetic Resonance Angiography
  • Magnetic Resonance Imaging
  • Middle Aged
  • Purpura, Thrombocytopenic, Idiopathic / diagnosis
  • Purpura, Thrombocytopenic, Idiopathic / drug therapy*
  • Time Factors
  • Treatment Outcome
  • gamma-Globulins / administration & dosage
  • gamma-Globulins / adverse effects*

Substances

  • Immunoglobulins, Intravenous
  • gamma-Globulins
  • Aspirin