Cytotoxic triterpenoids from Abies recurvata

Yong-Li Li; Yan-Xia Gao; Xian-Wen Yang; Hui-Zi Jin; Ji Ye; Luke Simmons; Ning Wang; Andre Steinmetz; Wei-Dong Zhang

doi:10.1016/j.phytochem.2012.05.032

Cytotoxic triterpenoids from Abies recurvata

Phytochemistry. 2012 Sep:81:159-64. doi: 10.1016/j.phytochem.2012.05.032. Epub 2012 Jun 29.

Authors

Yong-Li Li¹, Yan-Xia Gao, Xian-Wen Yang, Hui-Zi Jin, Ji Ye, Luke Simmons, Ning Wang, Andre Steinmetz, Wei-Dong Zhang

Affiliation

¹ School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.

PMID: 22749257
DOI: 10.1016/j.phytochem.2012.05.032

Abstract

Nine triterpenoids (neoabiestrines A-I, 1-9) including six rearranged lanostanes (1-6) and a rare cycloart-7-ene (7) were isolated from Abies recurvata together with ten known compounds. Their structures were determined by detailed analysis of NMR and MS spectroscopic data. The absolute configurations of 1 and 8 were determined by Cu-Ka X-ray crystallography. Compound 6 showed potent anti-proliferative effect against THP-1 tumor cells with an IC(50) value of 17.8 μg/mL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abies / chemistry*
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Cell Line, Tumor
Crystallography, X-Ray
Humans
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy / methods
Molecular Conformation
Plant Extracts / chemistry
Stereoisomerism
Triterpenes / chemistry*
Triterpenes / isolation & purification
Triterpenes / pharmacology

Substances

Antineoplastic Agents, Phytogenic
Plant Extracts
Triterpenes
neoabiestrine F