Treatment failure of pharyngeal gonorrhoea with internationally recommended first-line ceftriaxone verified in Slovenia, September 2011

Euro Surveill. 2012 Jun 21;17(25):20200.

Abstract

We describe the second case in Europe of verified treatment failure of pharyngeal gonorrhoea, caused by an internationally occurring multidrug-resistant gonococcal clone, with recommended first-line ceftriaxone 250 mg in Slovenia. This is of grave concern since ceftriaxone is last remaining option for empirical treatment. Increased awareness of ceftriaxone failures, more frequent test-of-cure, strict adherence to regularly updated treatment guidelines, and thorough verification/falsification of suspected treatment failures are essential globally. New effective treatment options are imperative.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use*
  • Ceftriaxone / therapeutic use*
  • Drug Resistance, Bacterial
  • Female
  • Gonorrhea / diagnosis
  • Gonorrhea / drug therapy*
  • Gonorrhea / microbiology
  • Heterosexuality
  • Humans
  • Injections, Intramuscular
  • Male
  • Microbial Sensitivity Tests
  • Neisseria gonorrhoeae / drug effects*
  • Neisseria gonorrhoeae / genetics
  • Neisseria gonorrhoeae / isolation & purification*
  • Pharyngeal Diseases / diagnosis
  • Pharyngeal Diseases / drug therapy*
  • Pharyngeal Diseases / microbiology
  • Polymerase Chain Reaction
  • Practice Guidelines as Topic
  • Sequence Analysis, DNA
  • Slovenia
  • Treatment Failure

Substances

  • Anti-Bacterial Agents
  • Ceftriaxone