Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506)

J Bacteriol. 2012 Jul;194(14):3756-7. doi: 10.1128/JB.00692-12.

Abstract

The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gene Expression Regulation, Bacterial / physiology
  • Genome, Bacterial*
  • Immunosuppressive Agents / metabolism*
  • Molecular Sequence Data
  • Streptomyces / classification
  • Streptomyces / genetics*
  • Streptomyces / metabolism*
  • Tacrolimus / metabolism*

Substances

  • Immunosuppressive Agents
  • Tacrolimus

Associated data

  • GENBANK/AJSZ00000000