Diversity oriented approach to crownophanes by enyne metathesis and Diels-Alder reaction as key steps

J Org Chem. 2012 Jul 20;77(14):6314-8. doi: 10.1021/jo300766f. Epub 2012 Jul 10.

Abstract

Various crownophanes are assembled starting with simple phenol derivatives such as catechol, resorcinol, and hydroquinone. Here, cross-enyne metathesis (CEM) and Diels-Alder (DA) reaction have been used as key steps. This strategy has embedded six diversity points.