A new butanolide compound from the aerial part of Lindera akoensis with anti-inflammatory activity

Molecules. 2012 May 31;17(6):6585-92. doi: 10.3390/molecules17066585.

Abstract

A new butanolide, 3β-((E)-dodec-1-enyl)-4β-hydroxy-5β-methyldihydrofuran-2-one (1) and four known butanolides: Akolactone A (2), (3Z,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (3), (3E,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (4) and dihydroisoobtusilactone (5), were isolated from the aerial parts of Lindera akoensis. These butanolides showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitrite in RAW264.7 cell, with IC₅₀ values of 1.4-179.9 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology*
  • Cell Line
  • Cell Survival / drug effects
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / pharmacology*
  • Furans / chemistry
  • Furans / pharmacology*
  • Lindera / chemistry*
  • Macrophages / drug effects
  • Macrophages / immunology
  • Mice
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Components, Aerial / chemistry*

Substances

  • 3beta-((E)-dodec-1-enyl)-4beta-hydroxy-5beta-methyldihydrofuran-2-one
  • Anti-Inflammatory Agents
  • Drugs, Chinese Herbal
  • Furans