Abstract
In silico screening of metazoan genome data identified multiple endogenous hepadnaviral elements in the budgerigar (Melopsittacus undulatus) genome, most notably two elements comprising about 1.3 × and 1.0 × the full-length genome. Phylogenetic and molecular dating analyses show that endogenous budgerigar hepatitis B viruses (eBHBV) share an ancestor with extant avihepadnaviruses and infiltrated the budgerigar genome millions of years ago. Identification of full-length genomes with preserved key features like ε signals could enable resurrection of ancient BHBV.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Genome, Viral*
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Hepadnaviridae / chemistry
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Hepadnaviridae / classification
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Hepadnaviridae / genetics*
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Hepadnaviridae / isolation & purification*
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Hepadnaviridae Infections / veterinary*
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Hepadnaviridae Infections / virology*
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Humans
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Molecular Sequence Data
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Phylogeny
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Proviruses / chemistry
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Proviruses / classification
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Proviruses / genetics*
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Proviruses / isolation & purification
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Sequence Alignment
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Viral Proteins / chemistry
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Viral Proteins / genetics
Associated data
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GDB/JQ978774
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GENBANK/BK008520
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GENBANK/BK008521
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GENBANK/JQ978775
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GENBANK/JQ978776
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GENBANK/JQ978777
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GENBANK/JQ978778
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GENBANK/JQ978779
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GENBANK/JQ978780
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GENBANK/JQ978781
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GENBANK/JQ978782
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GENBANK/JQ978783
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GENBANK/JQ978784