Non-small cell bronchial carcinoma metastasizing into a prolactin-producing pituitary adenoma

Int J Surg Pathol. 2013 Feb;21(1):68-71. doi: 10.1177/1066896912449478. Epub 2012 Jun 10.

Abstract

This study presents the case of a 66-year-old man with a non-small cell bronchial carcinoma that metastasized into a prolactin (PRL)-producing pituitary adenoma. The pituitary adenoma cells were immunoreactive for PRL and vascular endothelial growth factor (VEGF). It is hypothesized that VEGF and PRL played a role in the development of metastasis within the adenoma.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers, Tumor / metabolism
  • Bronchial Neoplasms / metabolism
  • Bronchial Neoplasms / pathology*
  • Carcinoma, Non-Small-Cell Lung / metabolism
  • Carcinoma, Non-Small-Cell Lung / secondary*
  • Fatal Outcome
  • Humans
  • Male
  • Pituitary Neoplasms / metabolism
  • Pituitary Neoplasms / secondary*
  • Prolactin / metabolism
  • Prolactinoma / metabolism
  • Prolactinoma / pathology*
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Biomarkers, Tumor
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • Prolactin