The pharmacokinetics and safety of twice daily i.v. BU during conditioning in pediatric allo-SCT recipients

Bone Marrow Transplant. 2013 Jan;48(1):19-25. doi: 10.1038/bmt.2012.105. Epub 2012 Jun 11.

Abstract

Intravenous BU divided four times daily (q6 h) has been shown to be safe and effective in pediatric allo-SCT recipients. Though less frequent dosing is desirable, pharmacokinetic (PK) data on twice daily (q12 h) i.v. BU administration in pediatric allo-SCT recipients is limited. We prospectively examined the PK results in a cohort of pediatric allo-SCT recipients receiving i.v. BU q12 h as part of conditioning before allo-SCT. BU levels were obtained after the first dose of conditioning. PK parameter analysis (n=49) yielded the following 95% confidence intervals (CI₉₅): weight-normalized volume of distribution: 0.65-0.73 L/kg; t(1/2): 122-147 min; weight-normalized clearance (CL(n)): 3.4-4.3 mL/min/kg; and area under the curve: 1835-2180 mmol × min/L. From these results, a steady state concentration was calculated with CI₉₅ between 628-746 ng/mL. Comparison between recipients ≤4 vs >4 years old revealed significant differences in t(1/2) (mean: 115 vs 146 min, P=0.008) and CL(n) (mean: 4.4 vs 3.5 mL/min/kg, P=0.038). Intravenous BU q12 h had a comparable PK to i.v. BU q6 h PK seen in the literature, and in pediatric allo-SCT recipients, is a feasible, attractive alternative to i.v. q6h dosing.

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Age Factors
  • Antineoplastic Agents, Alkylating / administration & dosage
  • Antineoplastic Agents, Alkylating / adverse effects
  • Antineoplastic Agents, Alkylating / blood
  • Antineoplastic Agents, Alkylating / pharmacokinetics*
  • Busulfan / administration & dosage
  • Busulfan / adverse effects
  • Busulfan / blood
  • Busulfan / pharmacokinetics*
  • Child
  • Child, Preschool
  • Cohort Studies
  • Drug Administration Schedule
  • Drug Therapy, Combination / adverse effects
  • Female
  • Follow-Up Studies
  • Graft Survival / drug effects
  • Half-Life
  • Humans
  • Infant
  • Infusions, Intravenous
  • Male
  • Metabolic Clearance Rate
  • Myeloablative Agonists / administration & dosage
  • Myeloablative Agonists / adverse effects
  • Myeloablative Agonists / blood
  • Myeloablative Agonists / pharmacokinetics*
  • Stem Cell Transplantation / adverse effects*
  • Transplantation Conditioning / adverse effects*
  • Transplantation, Homologous

Substances

  • Antineoplastic Agents, Alkylating
  • Myeloablative Agonists
  • Busulfan