[Effect of new phenibut salts on psychic and physical development of posterity in rats with experimental gestosis]

Eksp Klin Farmakol. 2012;75(3):18-20.
[Article in Russian]

Abstract

Phenibut salts with citric and salicylic acids--compounds RSPU-147 and RSPU-189, respectively--positively influence the psychic (increase in the locomotor and position-finding activity in the open field test and retention of memorable track in the CROA test) and physical (in the revolution, negative geo-taxis, avoidance, and muscular force tests) development of posterity, born from females with gestosis caused by the replacement of drinking water by 1.8% NaCl solution during the period of gestation.

MeSH terms

  • Animals
  • Animals, Newborn
  • Behavior, Animal
  • Female
  • Growth and Development / drug effects*
  • Pre-Eclampsia / physiopathology*
  • Pregnancy
  • Rats
  • gamma-Aminobutyric Acid / administration & dosage
  • gamma-Aminobutyric Acid / analogs & derivatives*

Substances

  • gamma-Aminobutyric Acid
  • 4-amino-3-phenylbutyric acid