Glioblastoma cancer stem cells--from concept to clinical application

Cancer Lett. 2013 Sep 10;338(1):32-40. doi: 10.1016/j.canlet.2012.05.033. Epub 2012 Jun 2.

Abstract

Ten years after the first description of cancer stem cells (CSCs) in glioblastoma (GBM), the initial concept of CSC has been challenged and our understanding of cellular heterogeneity within malignant brain tumors became more complex. The increasing knowledge on CSC also influences preclinical research and clinical practice. This review therefore describes current concepts and controversies on CSC in GBM and summarizes the recent progress how the CSC hypothesis is about to translate into preclinical and clinical application.

Keywords: CD133; Cancer stem cells; Chemoresistance; Glioblastoma; Radioresistance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AC133 Antigen
  • Antigens, CD / metabolism
  • Biomarkers, Tumor / metabolism
  • Brain Neoplasms / genetics
  • Brain Neoplasms / metabolism
  • Brain Neoplasms / pathology*
  • Cell Proliferation*
  • Glioblastoma / genetics
  • Glioblastoma / metabolism
  • Glioblastoma / pathology*
  • Glycoproteins / metabolism
  • Humans
  • Isocitrate Dehydrogenase / genetics
  • Mutation
  • Neoplastic Stem Cells / metabolism
  • Neoplastic Stem Cells / pathology*
  • Peptides / metabolism
  • Prognosis

Substances

  • AC133 Antigen
  • Antigens, CD
  • Biomarkers, Tumor
  • Glycoproteins
  • PROM1 protein, human
  • Peptides
  • Isocitrate Dehydrogenase