Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells

Bioorg Med Chem Lett. 2012 Jul 1;22(13):4314-7. doi: 10.1016/j.bmcl.2012.05.016. Epub 2012 May 22.

Abstract

A new class of hybrid chalcones (17a-l &18a-l) was synthesized by Claisen-Schmidt condensation. All compounds were characterized by (1)H NMR, IR and mass spectral analysis and tested for their cytotoxic activity against PC-3 (prostate cancer), HT-29 (colon cancer), B-16 (mouse macrophages) and NCI-H460 (lung cancer) cell lines. Three compounds 18i, 18j and 18l (IC(50)=8.4, 7.9 & 5.9 μM) showed significant activity against PC-3 cell line.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / therapeutic use
  • Antineoplastic Agents / toxicity
  • Apoptosis / drug effects
  • Cell Line, Tumor
  • Chalcone / analogs & derivatives*
  • Chalcone / therapeutic use
  • Chalcone / toxicity
  • Drug Screening Assays, Antitumor
  • Humans
  • Male
  • Mice
  • Prostatic Neoplasms / drug therapy
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Chalcone