Non heart beating organ donor: new experimental model in pigs

Acta Cir Bras. 2012 May;27(5):306-10. doi: 10.1590/s0102-86502012000500005.

Abstract

Purpose: To describe technical aspects of a new experimental model that simulates a non heart beating organ donor.

Methods: Landrace pigs were operated on and cardiac arrest was obtained by means of myocardial infarction and interruption of ventilator support.

Results: Mean cardiac frequency, systolic and diastolic blood pressure levels, central venous pressure, oxygen saturation and concentration of expired CO(2) dropout occurred at seven minutes after cardiac arrest.

Conclusion: The procedure was easily reproduced and a homogeneous circulatory failure could de obtained by the end of seven minutes. The model is suitable for further studies regarding abdominal organ transplantation.

MeSH terms

  • Animals
  • Carbon Dioxide / metabolism
  • Graft Survival
  • Heart Arrest* / physiopathology
  • Male
  • Models, Animal*
  • Organ Preservation*
  • Oxygen / metabolism
  • Swine
  • Tissue Donors*
  • Transplantation / methods

Substances

  • Carbon Dioxide
  • Oxygen