Abstract
Poly (lactide-co-glycolide) (PLGA) coupled with methoxy poly (ethylene glycol) (mPEG) or chlorin e6 (Ce6) was synthesized using the Steglich esterification method. PLGA-linked mPEG (PLGA-mPEG), PLGA-linked Ce6 (PLGA-Ce6), and Fe(3)O(4) were utilized to constitute multifunctional PLGA nanoparticles (∼160 nm) via the multi-emulsion W(1)/O/W(2) (water-in-oil-in-water) method. The photo-sensitizing properties of Ce6 molecules anchored to PLGA nanoparticles enabled in vivo luminescence imaging and photodynamic therapy for the tumor site. The encapsulation of Fe(3)O(4) allowed high contrast magnetic resonance (MR) imaging of the tumor in vivo. Overall, PLGA nanoparticles resulted in a significant tumor volume regression for the light-illuminated KB tumor in vivo and enhanced the contrast at the tumor region, compared to that of Feridex(®) (commercial contrast agent).
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line, Tumor
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Chlorophyllides
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Dextrans
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Female
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Ferric Compounds
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Humans
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KB Cells
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Lactic Acid / chemistry*
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Luminescent Measurements / methods
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Magnetic Resonance Imaging / methods*
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Magnetite Nanoparticles
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Nanoparticles*
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Neoplasms / diagnosis
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Neoplasms / pathology
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Neoplasms / therapy
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Photochemotherapy / methods*
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Photosensitizing Agents / administration & dosage
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Photosensitizing Agents / chemistry
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Polyesters
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Polyethylene Glycols / chemistry
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Polyglactin 910 / chemistry
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Polyglycolic Acid / chemistry*
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Polylactic Acid-Polyglycolic Acid Copolymer
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Porphyrins
Substances
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Chlorophyllides
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Dextrans
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Ferric Compounds
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Magnetite Nanoparticles
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Photosensitizing Agents
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Polyesters
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Porphyrins
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methoxypolyethyleneglycol-poly(lactic-co-glycolic acid)
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ferric oxide
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polyglycolic Acid
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Lactic Acid
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Polyglactin 910
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Polyethylene Glycols
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phytochlorin
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ferumoxides