Abstract
Spirastrellolides A (1) and B (3) have been isolated as free acids from a marine sponge Epipolasis sp. collected in the East China Sea. These compounds had been isolated from the Caribbean marine sponge Spirastrella coccinea after conversion to the methyl ester. We examined the cytotoxic activities of 1 and 3 and found that the activities of the free acids are comparable to those of the corresponding methyl esters.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Caribbean Region
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Macrolides / chemistry
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Macrolides / isolation & purification*
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Macrolides / pharmacology
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Marine Biology
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Molecular Structure
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Oceans and Seas
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Porifera / chemistry*
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Spiro Compounds / chemistry
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Spiro Compounds / isolation & purification*
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Spiro Compounds / pharmacology
Substances
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Antineoplastic Agents
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Macrolides
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Spiro Compounds
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spirastrellolide A
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spirastrellolide B