Translocation t(1;17)(q12;q25) with a clinical picture like of a proximal deletion of 1q: identification by in situ hybridization with chromosome 1-specific satellite DNA probes

S G Vorsanova; Y B Yurov; M B Kurbatov; L Z Kazantzeva

doi:10.1007/BF00197700

Translocation t(1;17)(q12;q25) with a clinical picture like of a proximal deletion of 1q: identification by in situ hybridization with chromosome 1-specific satellite DNA probes

Hum Genet. 1990 Dec;86(2):173-4. doi: 10.1007/BF00197700.

Authors

S G Vorsanova¹, Y B Yurov, M B Kurbatov, L Z Kazantzeva

Affiliation

¹ Institute of Pediatrics and Children's Surgery, MH of the USSR, Moscow.

PMID: 2265830
DOI: 10.1007/BF00197700

Abstract

The authors report a case of a balanced 1;17 translocation with breakpoints located in the secondary constriction of chromosome 1. This translocation is associated with pathological symptoms similar to those observed following a proximal deletion of 1q. We request contact with colleques who have observed similar, or related, cases of translocation with breakpoints in heterochromatic regions of human chromosomes.

MeSH terms

Child
Chromosome Banding
Chromosome Deletion*
Chromosomes, Human, Pair 1*
Chromosomes, Human, Pair 17*
DNA Probes
DNA, Satellite / genetics*
Humans
Karyotyping
Male
Nucleic Acid Hybridization
Translocation, Genetic*

Substances

DNA Probes
DNA, Satellite