Comparison of PapType to Digene Hybrid Capture 2, Roche linear array, and Amplicor for detection of high-risk human papillomavirus genotypes in women with previous abnormal pap smears

J Clin Microbiol. 2012 Aug;50(8):2796-8. doi: 10.1128/JCM.01064-12. Epub 2012 May 30.

Abstract

PapType human papillomavirus (HPV) assay was compared to Hybrid Capture 2 (HC2), Amplicor (Amp), and Linear Array (LA) HPV tests in 894 women undergoing management for a high-grade Pap smear abnormality. The sensitivity in detection of underlying high-grade histological diagnosis by PapType was 90.3% and by HC2 was 79.8%, while by Amp and LA it was 92.4% and 91.6%, respectively. The specificities were 52.5%, 55.3%, 49.4%, and 51.7% for PapType, HC2, Amp, and LA, respectively.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Cervix Uteri / pathology*
  • Cervix Uteri / virology*
  • Female
  • Humans
  • Molecular Diagnostic Techniques / methods*
  • Papanicolaou Test*
  • Papillomaviridae / classification
  • Papillomaviridae / genetics
  • Papillomaviridae / isolation & purification*
  • Papillomavirus Infections / diagnosis*
  • Papillomavirus Infections / virology
  • Sensitivity and Specificity
  • Vaginal Smears*
  • Virology / methods*