Abstract
Natural cyclopeptides are hot spots in chemical and pharmaceutical fields because of the wide spreading bio-resources, complex molecular structures and various bioactivities. Bio-producers of cyclopeptides distribute over almost every kingdom from bacteria to plants and animals. Many cyclopeptides contain non-coded amino acids and non-pepditic bonds. Most exciting characteristic of cyclopeptides is a range of interesting bioactivities such as antibiotics gramicidin-S (2), vancomycin (3) and daptomycin (4), immunosuppressive cyclosporin-A (1) and astin-C (8), and anti-tumor aplidine (5), RA-V (6) and RA-VII (7). Compounds 1-4 are being used in clinics; compounds 5-8 are in the stages of clinical trial or as a candidate for drug research. In this review, the progress in chemical and bioactive studies on these important natural bioactive cyclopeptides 1-8 are introduced, mainly including discovery, bioactivity, mechanism, QSAR and synthesis.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / therapeutic use
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Cyclosporine / chemistry
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Cyclosporine / pharmacology
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Daptomycin / chemical synthesis
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Daptomycin / chemistry
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Daptomycin / pharmacology
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Depsipeptides / chemical synthesis
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Depsipeptides / chemistry
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Depsipeptides / therapeutic use
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Gramicidin / chemical synthesis
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Gramicidin / chemistry
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Gramicidin / pharmacology
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Humans
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Immunosuppression Therapy
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Immunosuppressive Agents* / chemical synthesis
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Immunosuppressive Agents* / chemistry
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Immunosuppressive Agents* / pharmacology
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Molecular Structure
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Neoplasms / drug therapy
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Peptides, Cyclic* / chemical synthesis
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Peptides, Cyclic* / chemistry
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Peptides, Cyclic* / pharmacology
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Peptides, Cyclic* / therapeutic use
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Quantitative Structure-Activity Relationship
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Vancomycin / chemical synthesis
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Vancomycin / chemistry
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Vancomycin / pharmacology
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Depsipeptides
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Immunosuppressive Agents
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Peptides, Cyclic
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astin C
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Gramicidin
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RA V
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Vancomycin
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Cyclosporine
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RA VII
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Daptomycin
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plitidepsin