Abstract
We report on the functionalization of ligand-free NaGdF(4):Er(3+), Yb(3+) upconverting nanoparticles with heparin and basic fibroblast growth factor (bFGF). These upconverting nanoparticles are used to obtain high-contrast images of HeLa cells. These images reveal that the heparin-bFGF functionalized nanoparticles show specific binding to the cell membrane.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis / drug effects
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Cell Membrane / metabolism
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Contrast Media / chemistry*
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Contrast Media / toxicity
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Fibroblast Growth Factor 2 / metabolism
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HeLa Cells
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Heparin / metabolism
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Humans
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Lanthanoid Series Elements / chemistry*
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Ligands
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Metal Nanoparticles / chemistry*
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Metal Nanoparticles / toxicity
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Microscopy, Fluorescence
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Protein Binding
Substances
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Contrast Media
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Lanthanoid Series Elements
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Ligands
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Fibroblast Growth Factor 2
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Heparin