Abi1, a critical molecule coordinating actin cytoskeleton reorganization with PI-3 kinase and growth signaling

Abstract

Coordination of actin cytoskeletal reorganization with growth and proliferation signals is a key cellular process that is not fully understood. PI-3 kinase is one of the central nodes for distributing growth and proliferation signals downstream from growth factor receptors to the nucleus. Although PI-3 kinase function has been associated with actin cytoskeleton remodeling, satisfactory explanations of the mechanisms mediating this regulation have been elusive. Here we propose that interaction of the Abi1 protein with the p85 regulatory subunit of PI-3 kinase represents the link between growth receptor signaling and actin cytoskeleton remodeling. This function of Abi1, which involves WAVE complex, was initially observed in macropinocytosis, and may explain the coincident dysregulation of PI-3 kinase and actin cytoskeleton in cancer.