Chondrosterins A-E, triquinane-type sesquiterpenoids from soft coral-associated fungus Chondrostereum sp

Mar Drugs. 2012 Mar;10(3):627-638. doi: 10.3390/md10030627. Epub 2012 Mar 13.

Abstract

The marine fungus Chondrostereum sp. was collected from a soft coral Sarcophyton tortuosum from the South China Sea. This fungus was cultured in potato dextrose broth medium and the culture broth was extracted with EtOAc. Five new triquinane-type sesquiterpenoids, chondrosterins A-E (1-5), and the known sesquiterpenoid hirsutanol C (6), were isolated. The structures were elucidated mainly on the basis of NMR, MS, and X-ray single-crystal diffraction data. Chondrosterin A (1) showed significant cytotoxic activities against cancer lines A549, CNE2, and LoVo with IC(50) values of 2.45, 4.95, and 5.47 μM, respectively.

Keywords: chondrosterins; Chondrostereum sp.; cytotoxic activities; marine fungus; sesquiterpenoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / microbiology*
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / pharmacology
  • Bridged-Ring Compounds / chemistry*
  • Bridged-Ring Compounds / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Chromatography, High Pressure Liquid
  • Drug Screening Assays, Antitumor
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Models, Molecular
  • Molecular Conformation
  • Polyporales / metabolism*
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / pharmacology
  • X-Ray Diffraction

Substances

  • Antibiotics, Antineoplastic
  • Bridged-Ring Compounds
  • Sesquiterpenes