Abstract
Three new cembranoids, sarcocrassocolides M-O (1-3), have been isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 1-3 were shown to exhibit moderate cytotoxicity toward a limited panel of cancer cell lines and display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein.
Keywords:
soft coral; Sarcophytoncrassocaule; anti-inflammatory activity; cytotoxic activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Cell Line, Tumor
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Cyclooxygenase 2 Inhibitors / isolation & purification
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Cyclooxygenase 2 Inhibitors / pharmacology
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Macrophages / drug effects
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Macrophages / enzymology
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Macrophages / metabolism
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Conformation
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Nitric Oxide Synthase Type II / antagonists & inhibitors
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Nitric Oxide Synthase Type II / biosynthesis
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Up-Regulation / drug effects
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cyclooxygenase 2 Inhibitors
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Diterpenes
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Nitric Oxide Synthase Type II