Abstract
Scientific evaluation of a patent aiming for the development of pyrazolopyridine derivatives as LRRK2 kinase inhibitors, a potential therapeutic target for combating Parkinson's disease.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiparkinson Agents / chemistry
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Antiparkinson Agents / pharmacology*
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Drug Design*
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Humans
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Molecular Structure
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Patents as Topic
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Protein Kinase Inhibitors / chemistry
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Protein Kinase Inhibitors / pharmacology*
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Protein Serine-Threonine Kinases / antagonists & inhibitors*
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Protein Serine-Threonine Kinases / metabolism
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Pyrazoles / chemistry
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Pyrazoles / pharmacology*
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Pyridines / chemistry
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Pyridines / pharmacology*
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Structure-Activity Relationship
Substances
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Antiparkinson Agents
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Protein Kinase Inhibitors
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Pyrazoles
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Pyridines
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pyrazolopyridine
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LRRK2 protein, human
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Protein Serine-Threonine Kinases