Abstract
A human telomeric G-quadruplex (G4DNA) metalloenzyme, assembled with G4DNA and Cu(2+) ions, can catalyze the enantioselective Friedel-Crafts (F-C) reaction in water with good enantioselectivity (up to 75% ee). Furthermore, we found that the absolute configuration and the enantioselectivity of the product largely depend on the conformation and the sequence of G4DNA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biocatalysis
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Copper / chemistry
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Copper / metabolism*
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G-Quadruplexes*
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Humans
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Imidazoles / chemistry
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Imidazoles / metabolism*
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Indoles / chemistry
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Indoles / metabolism*
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Metalloproteins / chemistry
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Metalloproteins / metabolism*
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Molecular Structure
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Stereoisomerism
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Water / chemistry*
Substances
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Imidazoles
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Indoles
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Metalloproteins
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Water
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Copper