Review analysis of the association between the prevalence of activated brown adipose tissue and outdoor temperature

ScientificWorldJournal. 2012:2012:793039. doi: 10.1100/2012/793039. Epub 2012 Apr 19.

Abstract

Brown adipose tissue (BAT) is important for regulating body weight. Environmental temperature influences BAT activation. Activated BAT is identifiable using (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT). (18)F-FDG PET/CT scans done between June 2005 and May 2009 in our institution in tropical southern Taiwan and BAT studies from PubMed (2002-2011) were reviewed, and the average outdoor temperatures during the study periods were obtained. A simple linear regression was used to analyze the association between the prevalence of activated BAT (P) and the average outdoor temperature (T). The review analysis for 9 BAT studies (n = 16, 765) showed a significant negative correlation (r = -0.741, P = 0.022) between the prevalence of activated BAT and the average outdoor temperature. The equation of the regression line is P(%) = 6.99 - 0.20 × T (°C). The prevalence of activated BAT decreased by 1% for each 5°C increase in average outdoor temperature. In a neutral ambient temperature, the prevalence of activated BAT is low and especially rare in the tropics. There is a significant linear negative correlation between the prevalence of activated BAT and the average outdoor temperature.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue, Brown / diagnostic imaging
  • Adipose Tissue, Brown / metabolism*
  • Fluorodeoxyglucose F18
  • Humans
  • Linear Models
  • Multimodal Imaging / methods
  • Obesity / epidemiology
  • Obesity / metabolism
  • Positron-Emission Tomography
  • Prevalence
  • Review Literature as Topic*
  • Taiwan / epidemiology
  • Temperature*
  • Tomography, X-Ray Computed

Substances

  • Fluorodeoxyglucose F18