The objective of the present article was to examine the role of origin and quantity of selected natural oils and waxes in the determination of the thermal properties and hardness of stick bases. The natural oils and waxes selected for the study were sunflower, castor, jojoba, and coconut oils. The selected waxes were yellow beeswax, candelilla wax, and carnauba wax. The hardness of the formulations is a critical parameter from the aspect of their application. Hardness was characterized by the measurement of compression strength along with the softening point, the drop point, and differential scanning calorimetry (DSC). It can be concluded that coconut oil, jojoba oil, and carnauba wax have the greatest influence on the thermal parameters of stick bases.