Generation of second messengers in Plasmodium

Alexandre Budu; Célia R S Garcia

doi:10.1016/j.micinf.2012.04.012

Generation of second messengers in Plasmodium

Microbes Infect. 2012 Aug;14(10):787-95. doi: 10.1016/j.micinf.2012.04.012. Epub 2012 Apr 26.

Authors

Alexandre Budu¹, Célia R S Garcia

Affiliation

¹ Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, Rua do Matão, travessa 14, número 101, CEP 05508-090, São Paulo, Brazil.

PMID: 22584103
DOI: 10.1016/j.micinf.2012.04.012

Abstract

Signalling in malaria parasites is a field of growing interest as its components may prove to be valuable drug targets, especially when one considers the burden of a disease that is responsible for up to 500 million infections annually. The scope of this review is to discuss external stimuli in the parasite life cycle and the upstream machinery responsible for translating them into intracellular responses, focussing particularly on the calcium signalling pathway.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Plasmodium / metabolism
Plasmodium / physiology*
Second Messenger Systems*
Signal Transduction*
Stress, Physiological