Abstract
A series of novel 1,3-dimethylisocyanurates has been synthesized as potential inhibitors of β-ketoacyl synthase in mycobacteria. Most of the 25 compounds described and tested for their activity against M. tuberculosis have a bacteriostatic effect, comparable and even higher that of first-line antituberculosis drugs. These compounds are nontoxic, species-specific, exhibiting no activity against other bacterial species.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
MeSH terms
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Amides / chemistry
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / toxicity
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Chemistry Techniques, Synthetic
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Mice
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects
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Rats
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Structure-Activity Relationship
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Sulfonic Acids / chemistry
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Triazines / chemical synthesis*
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Triazines / chemistry
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Triazines / pharmacology*
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Triazines / toxicity
Substances
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Amides
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Anti-Bacterial Agents
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Sulfonic Acids
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Triazines
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isocyanuric acid