Rapid urinary trypsinogen-2 test in the early diagnosis of acute pancreatitis: a meta-analysis

Clin Biochem. 2012 Sep;45(13-14):1051-6. doi: 10.1016/j.clinbiochem.2012.04.028. Epub 2012 May 7.

Abstract

Objectives: Urinary trypsinogen-2 has been implicated as a promising biomarker for the early diagnosis of acute pancreatitis (AP). The meta-analysis was used to establish the overall accuracy of urinary trypsinogen-2 test for diagnosing AP.

Methods: Based on comprehensive searches of the PubMed and Embase databases, we identified and abstracted outcome data from all articles evaluating the diagnostic value of urinary trypsinogen-2. A summary estimate for sensitivity, specificity, 95% confidence region and 95% prediction region was calculated using the bivariate random-effects approach.

Results: The meta-analysis included 13 studies (2342 patients, the proportion of severe AP from 13.21% to 30.00%). Overall, the pooled sensitivity was 82.3% (95%CI 79.3%-85.1%) and specificity was 93.5% (95%CI 92.2%-94.6%). The diagnostic odds ratios (DOR) was 85.23 (95%CI 40.14-180.99). The area under the summary ROC curve (AUC) was 0.9673.

Conclusion: The urinary trypsinogen-2 test is a reliable and rapid method for the early diagnosis of AP.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Area Under Curve
  • Biomarkers / urine
  • Confidence Intervals
  • Databases, Factual
  • Early Diagnosis
  • Female
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Pancreatitis / diagnosis*
  • Pancreatitis / epidemiology
  • Publication Bias
  • Reagent Kits, Diagnostic / standards*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Trypsin / urine*
  • Trypsinogen / urine*
  • Young Adult

Substances

  • Biomarkers
  • Reagent Kits, Diagnostic
  • PRSS2 protein, human
  • Trypsinogen
  • Trypsin