Late onset necrotizing enterocolitis in infants following use of a xanthan gum-containing thickening agent

Jennifer Beal; Benson Silverman; Jodeanne Bellant; Thomas E Young; Karl Klontz

doi:10.1016/j.jpeds.2012.03.054

Late onset necrotizing enterocolitis in infants following use of a xanthan gum-containing thickening agent

J Pediatr. 2012 Aug;161(2):354-6. doi: 10.1016/j.jpeds.2012.03.054. Epub 2012 May 9.

Authors

Jennifer Beal¹, Benson Silverman, Jodeanne Bellant, Thomas E Young, Karl Klontz

Affiliation

¹ Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Riverdale, MD 20770, USA. Jennifer.Beal@fda.hhs.gov

PMID: 22575248
DOI: 10.1016/j.jpeds.2012.03.054

Abstract

Adverse event reports submitted to the US Food and Drug Administration suggested a possible association between necrotizing enterocolitis and ingestion of a commercial feed thickener by premature infants. Review in 2011 of 22 cases with exposure revealed a distinct illness pattern.

Published by Mosby, Inc.

MeSH terms

Deglutition Disorders / therapy
Enterocolitis, Necrotizing / chemically induced*
Enterocolitis, Necrotizing / diagnosis
Enterocolitis, Necrotizing / microbiology
Food Additives / adverse effects*
Gastroesophageal Reflux / therapy
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / chemically induced*
Infant, Premature, Diseases / therapy
Milk, Human
Polysaccharides, Bacterial / adverse effects*

Substances

Food Additives
Polysaccharides, Bacterial
xanthan gum