Multifunctionalized mesoporous silica nanoparticles for the in vitro treatment of retinoblastoma: Drug delivery, one and two-photon photodynamic therapy

Int J Pharm. 2012 Aug 1;432(1-2):99-104. doi: 10.1016/j.ijpharm.2012.04.056. Epub 2012 Apr 28.

Abstract

In this work, we focused on mesoporous silica nanoparticles (MSN) for one photon excitated photodynamic therapy (OPE-PDT) combined with drug delivery and carbohydrate targeting applied on retinoblastoma, a rare disease of childhood. We demonstrate that bitherapy (camptothecin delivery and photodynamic therapy) performed with MSN on retinoblastoma cancer cells was efficient in inducing cancer cell death. Alternatively MSN designed for two-photon excited photodynamic therapy (TPE-PDT) were also studied and irradiation at low fluence efficiently killed retinoblastoma cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / administration & dosage*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Camptothecin / administration & dosage*
  • Camptothecin / chemistry
  • Cell Line, Tumor
  • Drug Carriers / administration & dosage*
  • Drug Carriers / chemistry
  • Endocytosis
  • Galactose / administration & dosage
  • Galactose / chemistry
  • Humans
  • Mannose / administration & dosage
  • Mannose / chemistry
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry
  • Photochemotherapy*
  • Retinal Neoplasms / drug therapy
  • Retinoblastoma / drug therapy
  • Silicon Dioxide / administration & dosage*
  • Silicon Dioxide / chemistry

Substances

  • Antineoplastic Agents, Phytogenic
  • Drug Carriers
  • Silicon Dioxide
  • Mannose
  • Galactose
  • Camptothecin