Abstract
We report the first establishment of in vitro cultivation and genotypic characterization of Leishmania siamensis isolated from an autochthonous disseminated dermal and visceral leishmaniasis in a Thai acquired immunodeficiency syndrome (AIDS) patient. The molecular identification has shown that the parasite was identical to L. siamensis, a recently described Leishmania species reported in the southern provinces of Thailand. The phylogenetic analysis has confirmed L. siamensis as closely related to the zoonotic Leishmania species L. enrietti.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS-Related Opportunistic Infections / complications
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AIDS-Related Opportunistic Infections / drug therapy
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AIDS-Related Opportunistic Infections / parasitology*
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Acquired Immunodeficiency Syndrome / complications
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Acquired Immunodeficiency Syndrome / drug therapy
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Acquired Immunodeficiency Syndrome / parasitology*
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Adult
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Anti-HIV Agents / therapeutic use
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Female
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Genes, Protozoan
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Humans
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Lamivudine / therapeutic use
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Leishmania / genetics*
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Leishmania / isolation & purification
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Leishmania / pathogenicity
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Leishmaniasis, Cutaneous / complications*
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Leishmaniasis, Cutaneous / drug therapy
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Leishmaniasis, Cutaneous / parasitology
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Leishmaniasis, Visceral / complications*
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Leishmaniasis, Visceral / drug therapy
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Leishmaniasis, Visceral / parasitology
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Nevirapine / therapeutic use
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Phylogeny
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Stavudine / therapeutic use
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Thailand / epidemiology
Substances
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Anti-HIV Agents
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Lamivudine
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Nevirapine
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Stavudine