Autochthonous disseminated dermal and visceral leishmaniasis in an AIDS patient, southern Thailand, caused by Leishmania siamensis

Am J Trop Med Hyg. 2012 May;86(5):821-4. doi: 10.4269/ajtmh.2012.11-0707.

Abstract

We report the first establishment of in vitro cultivation and genotypic characterization of Leishmania siamensis isolated from an autochthonous disseminated dermal and visceral leishmaniasis in a Thai acquired immunodeficiency syndrome (AIDS) patient. The molecular identification has shown that the parasite was identical to L. siamensis, a recently described Leishmania species reported in the southern provinces of Thailand. The phylogenetic analysis has confirmed L. siamensis as closely related to the zoonotic Leishmania species L. enrietti.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS-Related Opportunistic Infections / complications
  • AIDS-Related Opportunistic Infections / drug therapy
  • AIDS-Related Opportunistic Infections / parasitology*
  • Acquired Immunodeficiency Syndrome / complications
  • Acquired Immunodeficiency Syndrome / drug therapy
  • Acquired Immunodeficiency Syndrome / parasitology*
  • Adult
  • Anti-HIV Agents / therapeutic use
  • Female
  • Genes, Protozoan
  • Humans
  • Lamivudine / therapeutic use
  • Leishmania / genetics*
  • Leishmania / isolation & purification
  • Leishmania / pathogenicity
  • Leishmaniasis, Cutaneous / complications*
  • Leishmaniasis, Cutaneous / drug therapy
  • Leishmaniasis, Cutaneous / parasitology
  • Leishmaniasis, Visceral / complications*
  • Leishmaniasis, Visceral / drug therapy
  • Leishmaniasis, Visceral / parasitology
  • Nevirapine / therapeutic use
  • Phylogeny
  • Stavudine / therapeutic use
  • Thailand / epidemiology

Substances

  • Anti-HIV Agents
  • Lamivudine
  • Nevirapine
  • Stavudine