[Immunogenetics of type 1 diabetes mellitus--from fundamental ideas to medical practice]

L P Alekseev; I I Dedov; R M Khaitov; M N Boldyreva; D Iu Trofimov; V A Peterkova; T L Kuraeva; D D Abramov

[Immunogenetics of type 1 diabetes mellitus--from fundamental ideas to medical practice]

Vestn Ross Akad Med Nauk. 2012:(1):75-80.

[Article in Russian]

Authors

L P Alekseev, I I Dedov, R M Khaitov, M N Boldyreva, D Iu Trofimov, V A Peterkova, T L Kuraeva, D D Abramov

PMID: 22550715

Abstract

The review of studies of Russian researchers on theoretical and practical aspects of genetic predisposition to type 1 diabetes associated with immunity: HLA and not HLA genes. Most important for practical public health outcomes are evidence that HLA-genetic predisposition to type 1 diabetes is associated with the DRB1-genotype, consisting entirely of variants DRB1-genes associated with the development of T1D. It was also established that CTLA4 gene has an independent predictive value for T1D.

Publication types

English Abstract
Review

MeSH terms

Diabetes Mellitus, Type 1* / diagnosis
Diabetes Mellitus, Type 1* / genetics
Diabetes Mellitus, Type 1* / immunology
Genetic Association Studies
Genetic Predisposition to Disease*
Genetic Testing / methods*
HLA-DR Antigens* / genetics
HLA-DR Antigens* / immunology
Humans
Immunogenetic Phenomena*
Major Histocompatibility Complex / genetics
Major Histocompatibility Complex / immunology
Pedigree
Polymorphism, Genetic / immunology
Predictive Value of Tests

Substances

HLA-DR Antigens