Abstract
Cigarette smoke exposure generates both acute and chronic inflammatory cell infiltrates that are operative in numerous pulmonary disorders. Cigarette smoke induces a complex signaling cascade within the lung mediated by epithelial cells, lymphocytes, macrophages, and others. The net result is a destructive and self-perpetuating inflammatory environment that is capable of creating lung diseases such as emphysema, while simultaneously fueling lung tumor growth using both matrix-dependent and -independent means.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Humans
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Inflammation / immunology
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Inflammation / metabolism
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Leukocyte Elastase / immunology
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Leukocyte Elastase / metabolism
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Lung / enzymology
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Lung / immunology*
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Lung Neoplasms / enzymology
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Lung Neoplasms / immunology*
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Neutrophils / enzymology
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Neutrophils / immunology
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Pulmonary Disease, Chronic Obstructive / enzymology
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Pulmonary Disease, Chronic Obstructive / immunology*
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Pulmonary Emphysema / enzymology
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Pulmonary Emphysema / immunology*
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Smoking / immunology*
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Smoking / metabolism