A new and efficient method for the synthesis of 3,4-disubstituted pyrrolidine-2,5-diones

Eleonora D Ilieva; Nevena I Petkova; Rositca D Nikolova

doi:10.3390/molecules17054936

A new and efficient method for the synthesis of 3,4-disubstituted pyrrolidine-2,5-diones

Molecules. 2012 Apr 30;17(5):4936-49. doi: 10.3390/molecules17054936.

Authors

Eleonora D Ilieva¹, Nevena I Petkova, Rositca D Nikolova

Affiliation

¹ Sofia University St. Kliment Ohridski, Faculty of Chemistry and Pharmacy, 1, J. Bourchier Blvd., Sofia 1126, Bulgaria.

Abstract

A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzopyrans / chemistry
Coumarins / chemistry*
Crystallography, X-Ray
Magnetic Resonance Spectroscopy
Methane / analogs & derivatives*
Methane / chemistry
Molecular Structure
Nitroparaffins / chemistry*
Stereoisomerism
Succinimides / chemical synthesis*
Temperature

Substances

Benzopyrans
Coumarins
Nitroparaffins
Succinimides
Methane
nitromethane